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Statements Author contributions JX and HD designed the study

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Compounds such as, baicalin (144), silibinin (145), panaxadiol (146), and Bu-zhong-yi-qi decoction (147) have been shown to downregulate PD-1 or PD-L1 expression through modulation of upstream signaling pathways, including JAKSTAT, NF-B, and PI3KAKTmTOR signaling