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Lancet Diabetes Endocrinol 2021;9:212224 [DOI] [PubMed] [Google Scholar] 68

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This drug is widely used as an antifibrinolytic agent and has been found to inhibit plasminogenkeratinocyte interaction leading to decrease in activity of tyrosinase, thereby resulting in decreased synthesis of melanin from the melanocytes.[] Human keratinocytes secrete the urokinase-type plasminogen activator, which increases the activity of melanocytes leading to increased synthesis of melanin and the blockade of this effect may be the mechanism behind therapeutic effect of TA for the treatment of melasma.[] Glutathione is an anti-oxidant tri-peptide, which is normally present in humans and has also been tried successfully as a treatment modality for melasma

This prevents cravings and overeating, which can result in weight loss

Its advisable for anyone taking Dextromethorphan, especially those in vulnerable populations, to communicate openly with their healthcare provider about any adverse effects they experience

Coolsculpting in an out-patient treatment option that allows patients to resume normal daily activities following the procedure