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In 1958, Jack Preiss and Philip Handler discovered intermediate precursor molecules and enzymes involved in the NAD+ biosynthesis pathway

Four histological grades of melanosis have been defined as Grade 1 variants, with only a few cells containing pigment granules, up to grade 4, in which the pigmented cells are extended and are located below the muscularis mucosae, lymphatic vessels and regional lymph nodes

Side effects can include GI disturbance and joint, leg, or back pain

Leith et al., 2024

Drug is: Less available to bind renal cell membranes Preferentially delivered to reticuloendothelial system and infected tissues

Lu M, Wheeler MB, Leng XH, Boyd AE 3rd