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Human studies were prioritised, while preclinical studies were included when they provided mechanistic evidence relevant to taste signalling, brainstem integration, interoception, or food-reward pathways

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83 , 84 Collectively, these findings indicate that incretin signalling modulates the metabolicinflammatory interface of the brain, restoring homeostatic equilibrium under insulinresistant or neuroinflammatory conditions

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Ozempic is sometimes prescribed off-label for weight loss, but this should always be discussed with a healthcare provider.