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These are randomized controlled trials published in major journals and form the basis of FDA approval for weight management
Baum RP, Schuchardt C, Singh A, Chantadisai M, Robiller FC, Zhang J, et al
Briefly, sodium bicarbonate, glucose, sodium pyruvate, and all 20 amino acids (except cystine and serine), biotin (B4639, Sigma), and vitamin B12 (V6629, Sigma) were added to the DMEM medium (#D9800-28, USBiological, Salem, MA) to match standard IMDM, supplement with 15% human AB serum and 15% dialyzed FBS (#SH300790340, Cytiva Hyclone), along with 10 ng/mL interleukin-3, 50 ng/mL stem cell factor and 2IU/mL erythropoietin
The strongest interpretation is that formulation, route, condition, and study design determine how much confidence a claim deserves
But if your concerns are more systemic (e.g., eczema, chronic wounds), an injectable may be better indicated
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