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Additionally, several key clinical trial readouts delivered compelling data across multiple indications, for example (see Figure 1): Semaglutide : STEP-HFpEF (functional benefits in HFpEF), STEP-9 (pain reduction in knee osteoarthritis), STEP-10 (reversion to normoglycaemia in pre-diabetic, obese patients), ESSENCE (resolution of MASH, improvement in fibrosis) Tirzepatide : SUMMIT (risk reduction in HFpEF outcomes

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10.1038/ijo.2014.153 83

Of special relevance to our study, RNR consumes reducing equivalents supplied by GSH, as well as thioredoxin, in mammalian cells (Zahedi Avval & Holmgren, 2009