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Watkins JB, III

doi:10.1016/S0140-6736(15)60383-X DISCLAIMER: These statements have not been approved by the Food and Drug Administration

This timing can reduce awareness of early side effects and may suit people with unpredictable daytime schedules or those who prefer to manage hunger suppression during afternoon and evening meals

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This dual-pathway synergy also partially overcomes somatostatin suppression somatostatin primarily inhibits the cAMP pathway, so the Ca-mediated GHRP pathway retains activity even when somatostatin tone is high (Bowers et al., 1991)