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For instance, increasing plasma glycine through injections may transiently augment inhibitory neurotransmission (potentially producing a mild sedative or muscle-relaxant effect) and support anabolic processes such as collagen deposition or antioxidant synthesis

Ketamine abuse is also associated with impaired consciousness, dizziness, abdominal pain, and lower urinary tract symptoms

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Nadkarni, et al (2014)

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However, it is notable that long-term GLP-1RA treatment is believed to induce tolerance [17]