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Its a mix of historical precedent, cost, and risk management

This single alteration provides substantial resistance to enzymatic degradation, extending the peptide's utility in metabolic research

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96 Upon activation, phosphofructokinase 1 (PFK1) can bind to the transcription factor TEAD, stabilizing its interaction with YAP/TAZ in the nucleus, promoting YAP/TAZ transcriptional output, and impacting breast cancer progression