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Notably, the hydroxyl group at the C4 position of the tetrahydropyran ring of substrate 7 also stabilizes the GSH-thiolate through an additional hydrogen bond (Extended Data Fig
This modification can enhance the loading capacity and release control ability of drugs (Liang et al., 2025)
Nov-Dec 2012;25(6):969-75
Some recent studies have made a beginning in this direction
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