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Both reactions in the Rapoport-Luebering shunt are catalyzed by one multifunctional protein: 2,3-BPG mutase (BPGM) (EC 5.4.2.4).81,153 The mutase activity of this enzyme converts the glycolytic intermediate 1,3-BPG to 2,3-BPG

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During pregnancy, cleft lip and cleft palate can sometimes be confirmed using ultrasound