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In the Middle Ages, the botanist John Gerard noted possible uses for milk thistle

Therapeutic applications focus on insomnia and difficulty falling or staying asleep, insufficient deep sleep despite adequate sleep duration, sleep disruption from stress or irregular schedules, recovery optimization for athletes or high performers, circadian rhythm disorders from travel or shift work, sleep quality decline associated with aging, and comprehensive wellness protocols recognizing sleep as foundational to metabolic health, cognitive function, immune resilience, and longevity

F.BastA.HaenenG

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This pairing is widely investigated for musculoskeletal health, localized wound healing, and systemic tissue protection

Schlesinger, W