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Therefore, ipamorelin is best administered as subcutaneous injections, usually several times a day due to its short-half life of just 2 hours [2]

Neuen BL, Oshima M, Agarwal R, Arnott C, Cherney DZ, Edwards R, et al

For gut-targeted indications, it may be the superior route because high local concentrations in the GI tract are exactly what you want