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Not if you're optimizing for the mechanism

While such studies demonstrate improvements in surrogate markers, such as ALT, AST, and albumin, they are often underpowered to assess hard clinical endpoints like survival rates, incidence of HCC, or liver decompensation (Xiang et al., 2013

The newly approved 7.2 mg semaglutide injection, marketed as Wegovy HD, is intended for adults with obesity or adults who are overweight with at least one weightrelated condition, offering significantly greater weight loss than previously approved doses

PMID: 122 de BisschopCCaronFIngrandPBretonneauQDupuyOMeuriceJCet al

Clinical approaches for combination therapies in acne and PIH