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Hydrogen forms polar covalent bonds to more electronegative atoms such as oxygen, and because a hydrogen atom is quite small, the positive end of the bond dipole (the hydrogen) can approach neighboring nucleophilic or basic sites more closely than can other polar bonds

[1] Compounded medications are not subject to the same rigorous manufacturing standards and quality controls as FDA-approved drugs, which raises important considerations regarding consistency, sterility, and potency

However, compounded drugs pose a higher risk to patients than FDA-approved drugs because compounded drugs do not undergo FDA premarket review for safety, effectiveness or quality

Supplied as a sterile-filtered solution

doi: 10.1002/prp2.536 4 AlhadeffA

This caution among patients and providers can limit market penetration for these therapies