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People with CF on ivacaftor experienced fewer exacerbation events requiring antibiotics and hospitalization (Rowe et al., 2014
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A program without a target cannot be optimized through medicinal chemistry, cannot generate target-engagement biomarkers and cannot be de-risked for off-target liabilities
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Besides these roles, GSH also plays role in detoxification of methylglyoxal, formation of phytochelatins, interacts with plant hormones, other signaling molecules and its redox state triggers signal transduction, and also acts as a cofactor in several biochemical reactions
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