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This is the data pattern researchers cite when explaining retatrutide's mechanistic rationale: each step up in receptor engagement from GLP-1R alone, to GLP-1R plus GIPR, to all three receptors has so far corresponded with a step up in reported efficacy across these independent trial programs

However, it remains unclear whether any observed benefits result from direct immunomodulatory effects, improvements in metabolic health, weight reduction, or other indirect mechanisms