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Nat Methods, 11:85560 Cawley NX, Li Z, Loh YP (2016) 60 YEARS OF POMC: biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides

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Results: Intestinal organoids exhibited measurable GLP-1 secretion and circadian patterns in Per2 at the population level, that were lost in Bmal1 KO mice (period = 24 h, phase = 8 h, p 140 mg/dl (19.411.5 vs