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However, distant delivery of free fatty acids, or even Oleoyl-Glycerol and sodium taurocholate have shown negligible effects on peripheral levels of GLP-1 or PYY, satiety and glucose tolerance (311, 406, 407)
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Additionally, the effects of GLP-1RAs on cognitive processes are currently being explored, broadening our understanding of their therapeutic mechanism in controlling metabolism
Some people report benefit when switching formulations such as acetyl L-carnitine or propionyl L-carnitine
Hence, the action of dual GLP-1R/GcgR agonists likely results from a combination of central and peripheral mechanisms, at multiple target tissues
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