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Microglia with depleted GSH have an exacerbated ROS/RNS production, elevated pro-inflammatory cytokine release, impaired phagocytic clearance, and increased neurotoxic output ( As discussed, the interplay between astrocytes and microglia via modulation of GSH activity implies that GSH is not only a cellular antioxidant, but an important mediator of cross-talk between resident CNS immune cells

Surgical treatment While up to 30% of fistulas may close spontaneously, the location of the fistula affects the closure rate

However, the molecular events that promote these alterations are incompletely understood (6)

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