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Calcitriol also exerts rapid, non-genomic effects through the 1,25D-MARRS receptor (PDIA3), which is highly expressed in neurons, astrocytes, and endothelial cells (56, 75)

Thus, mitochondrial impairment plays a key role in paclitaxel-induced cognitive deficits by disrupting synaptic plasticity, neurogenesis, and overall brain energy metabolism

10.1210/en.143.2.511

If symptoms persist beyond two weeks, worsen, or come with chest pain, facial droop, slurred speech, or severe weakness, seek urgent care

In its April 2026 advisory, Health Canada listed examples of unauthorized injectable peptide drugs it had seized, including BPC-157, CJC-1295, DSIP, Epitalon, GHK-Cu, HCG, ipamorelin, KPV, Melanotan I and II, MOTS-c, NAD+, SS-31, TB-500 and retatrutide

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