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(vii) glutamine consumption by clear cell renal cell carcinoma in vitro leads to IL-23 secretion by macrophages and Tregs recruitment, possibly restraining antitumor immunity in humans too [189]

doi: 10.1002/glia.22303 65 SchulzKKronerADavidS

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The first is extracellular matrix biology, where fibroblast culture and rat wound-chamber studies from the Maquart and Simeon groups (1988-2000) reported stimulation of collagen synthesis, sulfated glycosaminoglycan synthesis and small proteoglycan expression, alongside upregulation of matrix metalloproteinase-2 and its tissue inhibitors, a simultaneous increase in both matrix deposition and matrix turnover

MSC-Exos have demonstrated the ability to aid in the regeneration of tissue injuries in various diseases and clinical scenarios, such as wound healing, cardiovascular diseases, and COVID-19 [187]