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Ongoing trials are comparing outcomes

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Beyond the canonical cAMP pathway, tirzepatide engagement of GLP-1R has been associated with recruitment of -arrestin scaffolds and internalization dynamics that differ from those of selective GLP-1R agonists, offering a mechanistic dimension relevant to receptor desensitization and biased agonism research

Smith RN, Mann NJ, Braue A, Mkelinen H, Varigos GA: The effect of a high- protein, low glycemic-load diet versus a conventional, high glycemic-load diet on biochemical parameters associated with acne vulgaris: a randomized, investigator-masked, controlled trial

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