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The intestinal lining is only one cell layer thickan incredibly delicate barrier that must simultaneously allow nutrient absorption while keeping toxins, bacteria, and undigested proteins out of the bloodstream

In the mice, the senescent cells damaged by doxorubicin successfully died off when FOXO4-DRI was introduced

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J Immunol 172(5):28532860 Kitadai Y et al (2000) Regulation of disease-progression genes in human gastric carcinoma cells by interleukin 8