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Yes, persistent or worsening fatigue despite GLP-1 treatment warrants medical review to investigate other potential causes such as anaemia, thyroid disorders, sleep apnoea, depression, or medication side effects

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With millions of Americans already taking GLP-1 medications and use continuing to grow, these effects on preventing and treating substance use disorders could have significant impact at the population level

36 Generally, drugs with smaller molecular weights are considered to have more potential in this regard