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1,4 SUSTAIN 5: add-on basal insulin 1,10 In adult patients with type 2 diabetes on basal insulin metformin Mean change in A1C from baseline at Week 30 Patients with A1C 8% at screening had their background basal insulin dose reduced by 20% at the start of the trial to limit the potential risk of hypoglycemia

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Timeline: What to Expect During Your First Month Week 1 to 2 of semaglutide therapy typically involves appetite suppression without dramatic scale changes

Personalization Through Genetic Insight The PlexusDx Precision Peptide Genetic Test ($99 add-on after your first month) analyzes GLP1R, GIPR, FTO (rs9939609), and MC4R (rs17782313) variants that relate to GLP-1 and related signaling pathways

Together, they aim to cover inflammation, blood flow, and tissue rebuilding all at once