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For instance, the oral bioavailability of THC is approximately 6%, whereas inhalational administration increases bioavailability by nearly fivefold (Naef et al., 2004)

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They cannot by themselves establish: A safe human amount A safe route of administration Long-term human safety Interaction risks Reproductive or developmental safety Clinical effectiveness Which individuals, if any, might be suitable for an authorised use The number of animal papers should not be presented as equivalent to a programme of large, well-controlled human clinical trials

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[19] Hollan, M