Traditional calorie restriction often triggers metabolic adaptationyour body burns fewer calories to conserve energy
1 SURMOUNT-1, 72-week study of adults with obesity using Zepbound (tirzepatide 15mg)
This may help the muscle seeker and endurance athlete to train for a longer duration and pack bigger muscle mass
These data support an effect of IL-13 to decrease total and reduced GSH through high 15LO1, PEBP1, and GPX4 activity, which is partially compensated by (a) increased expression/activity of SLC7A11 to enhance new intracellular GSH production and (b) increased export of GSSG
131 Mitochondrial enzyme pyruvate dehydrogenase kinases phosphorylate pyruvate dehydrogenase complexes to inhibit their activity, thereby transferring pyruvate flow from OXPHOS to aerobic glycolysis during platelet activation, enabling platelets to respond to various conditions, such as hypoxia or the presence of mitochondrial inhibitors
Because the drug raises heart rate and blood pressure, the article calls it unsuitable for people with cardiovascular risk factors generally
