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A decrease in bioenergetic efficiency is double-faced: it may be beneficial to cellular function through the reduction of reactive oxidative species production and the balancing of nutrient availability [272], but it may also contribute to increasing mitochondrial dysfunction and toxicity [273], which couldaccount for a significant proportion of adverse effects of prescription drugs [26]

doi: 10.1161/CIR.0000000000000558 190 ZhaoCNMengXLiYLiSLiuQTangGYet al

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Skin Brightening Supplements: Ingredients and Clinical Treatment Options Feb 28 9 min read This article provides an educational overview of ingredients commonly found in skin brightening supplements and how they have been studied in relation to skin health

Borbly E, Scheich B, Helyes Z

As mentioned in the Introduction, there are many factors that contribute to ROS including oxygen and blue light that can penetrate the cornea and lens and induce photochemical damage 16,20