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Current literature supports GLP-1R-mediated anti-inflammatory and neuroprotective effects in the retina 43

Tirzepatide appears to have lower rates of treatment discontinuation due to side effects in clinical trials

However, there are still questions around P9s mechanism, whether it's present in other bacterial species and whether it influences the secretion of other gut hormones, such as GLP-2 and peptide YY

Hypophagia and body weight loss by tirzepatide are accompanied by fewer GI adverse events compared to semaglutide in preclinical models