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PMID: 203 PotnisKCRossJSAnejaSGrossCPRichmanIB

If initial tests are nondiagnostic, radioactive iodine uptake (increased uptake) and thyroid ultrasound (diffuse thyroid enlargement) provide diagnostic information

(2023) highlight the importance of the estrobolome in regulating estrogen levels throughout a womans life, from menstruation to menopause

Most of the these are repurposed (95%), so the number of available marketed products is not a reflection of targeted product development

Nature 619 , E9E18 (2023)

p53 tumour-suppressor caution Because FOXO4-DRI intervenes in the p53 pathway, which is critical for tumour suppression, there is theoretical concern that interfering with p53 dynamics might carry oncogenic risk