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have shown that compared with intravenous glucose, the increase of plasma insulin level after oral glucose was greater, and the high level of insulin was maintained for a longer time, which provided a basis for intestinal factors to stimulate insulin secretion (Elrick et al., 1964)

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cAMP elevation induced by GLP-1 can lead to its downstream protein kinase A (PKA) activation and enhanced signaling via cAMP-activated guanine nucleotide exchange factor (Epac) (Holz, 2004

Australian guidelines from ANZCA and multiple endorsing societies emphasise not withholding medications prior to procedures, recommending that patients who have taken medication in the last four weeks should be considered unfasted [43]