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In the randomized Semaglutide Treatment Effect in People with Obesity (STEP) 1 trial (intent to treat: 1,961 adults with overweight or obesity without T2D), once-weekly subcutaneous semaglutide 2.4 mg resulted in greater weight loss compared with placebo over a 68-week period (estimated treatment difference 12.4 percentage points, 95% confidence interval (CI) 13.4, 11.5

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These benefits are likely driven by weight loss and improved metabolic health, but the evidence is still limited

Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P