Non-targeting siRNA was used as a negative control
Generally, healthcare providers start at a lower dosage to avoid severe nausea or gastrointestinal distress
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Relative contraindications requiring caution include active or suspected cancer (GHK-Cu promotes angiogenesis with concern about theoretically feeding tumors, though conflicting data shows documented anti-cancer gene expression effects requiring medical supervision), severe organ dysfunction (kidney or liver failure may slow peptide clearance), hemochromatosis or copper overload conditions, autoimmune disorders, and patients on immunosuppressants or blood thinners
Physiologically, it involves in many enzymes and hormones, such as xanthine oxidase, reproductive hormone, growth hormone, thyroid hormone, etc (Liangshan Mu et al., 2018
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