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In a murine Salmonella infection model 34 , we observed a small but significant reduction in bacterial burden in Peyers patches at both days 2 and 6 post treatment when antibiotics were combined with KL1 (Fig

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It's possible that lower doses of each medication might be sufficient when used together, potentially mitigating some of the side effects while maintaining efficacy

In lysosomes, the Fenton reaction involving iron ions produces OH, but the presence of GPX4 helps prevent membrane lipid peroxidation [145]

Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production