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doi: 10.1159/000122437 67 TamuraHJozakiMTanabeMShirafutaYMiharaYShinagawaMet al

These reactive oxygen species may subsequently interact with superoxide dismutase and glutathione, leading to reduced levels of these antioxidants, making the brains ability to cope with oxidative stress damage much reduced and further accelerating neuronal cell damage in the corresponding brain regions ( The glutamate hypothesis of schizophrenia suggests that the function of N-methyl-D-aspartate (NMDA) receptors is impaired in this disorder

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Efforts to further enhance enzyme stability, catalytic efficiency, and bioavailability through nanotechnology hold promise for advancing therapeutic outcomes in enzyme-based treatments

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Another challenge is ensuring long-term engraftment: probiotics often only transiently colonize, and FMT engraftment can wane with time if not maintained by diet or repeat dosing