[2] However, once stores are depleted, symptoms can include fatigue, weakness, constipation, loss of appetite, and neurological changes such as numbness, tingling, balance problems, and cognitive difficulties
Summary: For most people requiring oral supplementation, cyanocobalamin is the most commonly used and effective form of B12, whilst hydroxocobalamin injections are the preferred treatment for confirmed deficiency in UK clinical practice
Prevent this by inserting the needle at a slight angle and rotating puncture sites around the stopper surface with each use
Heymsfield, S
A single vial can last weeks while remaining sterile
Across this body of research, no significant toxicity has been reported at doses ranging from 1 g/kg to 10 mg/kg in rodent models