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It was conducted in accordance with Good Clinical Practice 19 and the Declaration of Helsinki, 20 and followed the accepted rules for interaction studies according to the US Food and Drug Administration (FDA) Guidance for Industry 21 and the European Medicines Agency (EMA) guidelines

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This extended pharmacokinetic profile allows the investigation of sustained amylin receptor engagement over longer periods than would be possible with native amylin

Furthermore, few in vivo pharmacokinetic studies, especially in large animals such as pigs, have been performed to assess post-application systemic drug exposure

Problems with intrinsic factor binding to ileal receptors in the diseased tissue leads to B12 deficiency

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