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The esophagus sits immediately adjacent to the trachea (windpipe)

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Studies have shown that semaglutide treatment, combined with lifestyle modifications, such as diet and exercise, can lead to significant and sustained weight loss compared to the placebo

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Access to GLP-1 medications for weight management in the UK is governed by specific NICE Technology Appraisals and NHS commissioning policies, which establish strict eligibility criteria

Endpoint Definitions and Statistical Approach The primary endpoint was MACE, defined as all-cause mortality, myocardial infarction, or stroke, assessed over 52 weeks using an as-treated design