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3 School of Pharmacy, Monash University, Bandar Sunway, Selangor, Malaysia

It also serves as an essential cofactor for non-redox NAD+-dependent enzymes, including sirtuins, CD38, and poly(ADP-ribose) polymerases (PARPs)

Front Physiol 29(15):1436897 White C, Yuan X, Schmidt PJ, Bresciani E, Samuel TK, Campagna D, Hall C, Bishop K, Calicchio ML, Lapierre A, Ward DM (2013) HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis

GGCT, a key enzyme in tumor metabolism, has been reported to be upregulated in several cancers, and its depletion can exert anticancer effects

Nrf2, functioning as a redox-sensitive transcription factor, is pivotal in the cellular antioxidant self-defense mechanism, safeguarding organs from oxidative stress primarily by modulating the transcriptional activation of the ARE

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