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Fluorescence readings were measured using a fluorescence plate reader (Spectramax Gemini EM) at 340/420 nm (Ex/Em wavelength)

In recent years, studies on SZ bodily fluids have consistently reported increased numbers of TLR4-positive monocytes and elevated TLR4 expression in the peripheral blood of schizophrenia patients (149, 153155), suggesting that TLR4 upregulation is a key factor in the immunopathological process of schizophrenia

The anti-inflammatory properties of melatonin have also been extensively studied in models of cardiac sepsis 78,79,82 , where melatonin blunted the NF-B/NLRP3 connection and activation 78,79,82

10.1155/2017/9349487 26 HuangR.KeW.HanL.LiuY.ShaoK.JiangC.et al

They are the same compound, which is a tripeptide that consists of amino acids: L-glutamate, glycine, and L-cysteine

Frst P, Stehle P