Beyond obvious effects on energy balance, dietary quality can also influence obesity risk through changes in metabolic adaptation due to a high refined carbohydrate diet, in resting energy expenditure (such as through brown or beige adipose tissue thermogenesis), in microbiome calorie utilization (with corresponding greater or lesser utilization by the host tissues), and in epigenetic or trans -generational risk of obesity [81,82]
While this supports weight loss, rapid weight reduction can sometimes lead to muscle loss if strength training is not included
Curely can be a faster route
Liver fat, cardiovascular markers, and body composition continue to improve throughout this extended treatment period
Clin Chim Acta (2020) 502:21421
NICE guidance (TA875) supports the use of semaglutide 2.4 mg (Wegovy) for adults with a BMI of 35 kg/m or above alongside at least one weight-related condition, within a specialist weight management service (with lower BMI thresholds applicable for certain ethnic groups and other commissioning criteria)
