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Patel R, Varghese JF, Yadav UCS Crosstalk between adipose tissue, macrophages, and other immune cells development of obesity and inflammation-induced metabolic diseases

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(1992) described the IGF-1 LR3 analog and documented its dramatically reduced IGFBP binding compared to native IGF-1, establishing the pharmacokinetic rationale for its use as a research tool (PMID 1601853)