First, isolate newly identified microbial metabolites that modulate systemic FTN homeostasis, establish their molecular targets and signaling cascades in intestinal epithelial cellsin particular, how they interact with the dimerization of HIF-2/ARNT
This bypasses first-pass metabolism in the liver and avoids the stomach entirely
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The primary end point is the reduction in blood glucose levels (HbA1c) at the 40th week of treatment