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Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

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Any long-term safety data in humans are absent

The study established the mechanism: PTD-DBM interferes with the binding of CXXC5 to Dishevelled, activating the Wnt/beta-catenin pathway

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It was originally identified as a fragment derived from a larger protein found in human gastric juice, which sparked early scientific interest due to its unusual stability and biological activity under experimental conditions