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This article thoroughly traces the developmental milestones of GLP-1 drugs, from their initial discovery to their clinical application, detailing the evolution of diverse GLP-1 medications along with their distinct pharmacological properties

However, the available evidence remains limited due to a lack of adequately powered randomized controlled trials specifically targeting CHE, heterogeneity in study designs, and regional differences in the formulations used

Majasaari, J

In order to investigate specifically the role of mTORC1, we determined Exendin-4 effects on glucose consumption and uptake under inhibition of mTORC1 by Rapamycin, a compound that does not inhibit mTORC2 at the concentration tested (100 nM) (Fig

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+ Feldman, J