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10.1016/S2213-8587(21)00119-4 226

Ibuprofen and other NSAIDs, on the other hand, are infamous for causing gastritis, ulcers, and even bleeding in the GI tract

Cigarette smoke also contributes to mitochondrial DNA mutations, which increases ROS production and exacerbates neutrophilic airway inflammation (128)

Safety signals: FDA's significant-risk list cites serious adverse events associated with CJC-1295, including increased heart rate and systemic vasodilatory reaction

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To turn this mechanistic insight into a targeted therapy, we developed cartilage-targeting silk fibroin nanoparticles modified with a type II collagen-binding peptide WYRGRL for localized GLP-1RAs delivery (GLP-1RAs@NPs-WYRGRL)