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Alternative oral medications include other antibiotics like azithromycin (Zithromax) and minocycline, and the retinoid isotretinoin

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These results represent the greatest mean body-weight reduction reported to date for any incretin-based investigational therapy in a clinical trial of this duration.6 Although the triple-agonist mechanism offers substantial promise, glucagon receptor activation introduces theoretical safety concerns, including transient hyperglycemia, increased heart rate and potential hepatic effects

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