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Impact of semaglutide on fat mass, lean mass and muscle function in patients with obesity: the SEMALEAN study

Risks Versus Rewards Its all about risk versus reward with weight loss drugs

Current evidence, including magnetic resonance imaging studies, suggests that skeletal muscle alterations resulting from GLP-1 RA-induced weight loss, such as enhanced insulin sensitivity and reduced muscle fat infiltration, are adaptive, thereby improving muscle quality despite concurrent reductions in lean mass [112]

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The study did not find similar optic nerve risks with drugs such as Mounjaro or Zepbound, which use a different mechanism

Weve been using medications to successfully treat obesity for many years before GLP-1s, Dr