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All procedures performed on the animal models were approved by the Animal Care and Ethics Committee of POSTECH, and experiments were conducted in accordance with the approved guidelines

Mullin S, Smith L, Lee K, DSouza G, Woodgate P, Elflein J, et al

Biopharma companies face: Massive competition and potential market saturation with over 500 GLP-1-related clinical trials across 100+ indications Downward price pressure Highly restricted reimbursement and resistance to new indications Mechanism-based stratification can: Enrich clinical trials for responders (response biomarkers) Identify strong responder subgroups (complementary diagnostic) Differentiate competing assets Support development in new indications (biomarker-led indication switching) De-risk late-stage programs (clinical trial design) Past efforts to expand GLP-1s into new indications - such as the semaglutide Alzheimers trial - largely targeted broad patient groups defined by their clinical symptoms or diagnostic labels

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Of these, the study indicated 77 models exhibited normal insulin tolerance and 58 exhibited GH peak levels of less than three

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